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KMID : 1034820140100040411
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Molecular & Cellular Toxicology
2014 Volume.10 No. 4 p.411 ~ p.421
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Anti-fibrotic effects of Kyungheechunggan-tang on activated hepatic stellate cells and rat liver
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Yan Hea-Jung
Kwon Soo-Young
Kim Ki-Suk
Jeong Hyeon-Soo
Kim Yoo-Mi
Chung Won-Seok
Lee Jang-Hoon
Jang Hyeung-Jin
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Abstract
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Kyungheechunggan-tang (KHCGT), a mixture of 9 herbal aqueous extracts, is known in traditional Korean hepatoprotective medicine. To investigate the anti-fibrotic effect of KHCGT and its herbal ingredients, hepatic stellate cells (HSC) were activated by transforming growth factor-β (TGF-β), and the mRNA and protein expression levels of collagen type-1 (collagen-1) and α-smooth muscle actin (α-SMA) were measured. KHCGT and its 7 herbal ingredient among 9 herbal ingredients had an anti-fibrotic effect on activated HSC. Among the herbal samples, Artemisia capillaris, Salvia miltiorrhiza, Curcuma wenyujin showed the highest down-regulatory effect on α-SMA and collagen-1 mRNA expression. The liver tissues of dimethylnitrosamine (DMN)-induced rats were isolated to investigate the anti-fibrotic effect of KHCGT. This study provides understandings the effect of KHCGT and its ingredient herbal medicines on the activated HSC, and suggests herbal ingredient that plays a major role in anti-fibrotic effect of the KHCGT.
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KEYWORD
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Anti-fibrosis, Kyungheechunggan-tang (KHCGT), Collagen type-1 (collagen-1), α-smooth muscle actin (α-SMA)
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