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KMID : 1034820150110020187
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Molecular & Cellular Toxicology
2015 Volume.11 No. 2 p.187 ~ p.192
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Apoptotic effects of 1,5-bis-(5-nitro-2-furanyl)-1, K]4-pentadien-3-one on Drosophila SL2 cells
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Ren Yuan-Hang
Jin Hong
Tao Ke
Hou Tai-Ping
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Abstract
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In recent years, concerns over the potential impact of synthetic pesticides on the environment have promoted the research and development of environmentally friendly “green” pesticides. In the current study, we utilized a green biomimetic insecticide, 1,5-bis-(5-nitro-2-furanyl)-1,4-pentadien-3-one (compound C), to examine its cytotoxicity on an insect cell line, Drosophila melanogaster (SL2). Results from MTT assay showed cells treated with 100 μM of compound C for 48 h significantly inhibited the growth of SL2 cells by 87.71±0.96%. We subsequently attempted to illustrate the act on mechanism of compound C at the cellular level and found that it initiated apoptosis through a mitochondrial-dependent mechanism that increased the activity of caspase-3 and altered the cell cycle. These results suggest that the green biomimetic insecticide, compound C, is a novel and potent inducer of insect cell apoptosis.
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KEYWORD
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1,5-Bis-(5-nitro-2-furanyl)-1,4-pentadien-3-one, Biomimetic insecticide, Apoptosis, Cytotoxicity, SL2
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