|
KMID : 1034820150110020213
|
|
Molecular & Cellular Toxicology
2015 Volume.11 No. 2 p.213 ~ p.221
|
|
|
Coix seed extract attenuates the high-fat induced mouse obesity via PPARγ and C/EBPα a downregulation
|
|
Choi Eun-Kyeong
Cho Yu-Jeong
Yang Hea-Jung
Kim Ki-Suk
Lee In-Seung
Jang Jong-Chan
Kim Kang-Hoon
Bang Ji-Hyun
Kim Yu-Mi
Kim Se-Hoon
Cho Young-Hwan
Yoon Na-Young
Jang Young-Pyo
Song Mi-Yeon
Jang Hyeung-Jin
|
|
|
Abstract
|
|
|
|
The seed of the Coix lacryma-jobi L. var. ma-yuen Stapf seed (CLMS) extract has been prescribed to alleviate obesity by practitioners of traditional Korean medicine. Here, we investigated the effect of CLMS extract on PPARγ 2 and c/EBPα and obesity responses in C57BL/6J obese mice fed on a high fat diet. The mouse body index, blood profile, and fat accumulation levels in the liver were measured. The protein expression levels of PPARγ 2 and c/EBPα in the mice livers were also measured to determine the molecular mode-of-action of the reducing effect of CLMS extract on mouse adipogenesis. The results showed that HFD-induced mouse obesity, fat accumulation, and serum cholesterol were alleviated by the CLMS extract addition. Moreover, PPARγ 2 and C/EBPα, proteins, those are related to the adipogenesis, were downregulated by the CLMS extract intake considerably. This study indicates that as a food additive, CLMS extract has a reducing effect on the high-fat diet induced fat accumulation and on body weight through the downregulation of adipogenesis.
|
|
|
KEYWORD
|
|
|
Adipogenesis, C/EBPα, CLMS extract, Obesity, PPARα2
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|