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KMID : 1034820150110040395
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Molecular & Cellular Toxicology
2015 Volume.11 No. 4 p.395 ~ p.400
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Chronic effects of ketamine on gene expression changes in neurotransmitter receptors and regulators-A PCR-array study
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Tan Sijie
Zou Ju
Li Meixiang
Yew David T.
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Abstract
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Abuse of ketamine increased rapidly and chronic use of ketamine may result in dependence. We investigated the long-term effects of ketamine on anxiety like behaviors and gene expression changes in neurotransmitter receptors and regulators in mice. One month old ICR mice received sub-anesthetics dose of ketamine daily for 3 months. An Elevated Plus Maze (EPM) was employed to assess anxiety like behaviors in these mice and a PCR array was used to evaluate gene expression changes in neurotransmitter receptors and regulators in the brain. Ketamine decreased the time spent in the open arms and the visit of the open arms in the EPM. Drug dependence related genes, namely Prokr2, Npffr1 and GalR2 were differentially expressed in ketamine treated mice. The results of the present study depicted addictive potential of ketamine and may be beneficial for developing pharmacotherapies for ketamine dependence.
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KEYWORD
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Ketamine, Prefrontal cortex, PCR-array, addiction
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