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KMID : 1034820150110040457
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Molecular & Cellular Toxicology
2015 Volume.11 No. 4 p.457 ~ p.463
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(-)-4-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid presents antitumor activity in HT-29 human colon cancer in vitro and in vivo
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Liu Zhao Hui
Zhang Si Yu
Yu Yong Yang
Su Guo Qiang
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Abstract
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(-)-4-O-(4-O-β-D-glucopyranosylcaffeoyl) quinic acid (GQA), new compound isolated from Lonicera japonica, was found with the activity of inhibiting HIF-1. GQA exhibited anti-proliferative effects on a broad spectrum of tumor cell lines in HIF-1 dependent mechanism and could induce HT-29 cell apoptosis through the mitochondrial pathway. Oral administration of GQA showed significant inhibition against tumor growth of human colon carcinoma xenografted in nude mice. For the first time, this study provides scientific rational to develop GQA as a novel class of antitumor agents against the human colon carcinoma.
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KEYWORD
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(-)-4-O-(4-O-β-D-glucopyranosylcaffeoyl) quinic acid, HIF-1 inhibitory activity, Human colon carcinoma, HT-29 cell line, Nude mice
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