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KMID : 1034820160120020185
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Molecular & Cellular Toxicology
2016 Volume.12 No. 2 p.185 ~ p.195
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Protective effects of garlic oil against 1,3-dichloro-2-propanol-induced hepatotoxicity: role of CYP2E1 and MAPKs
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Ko Je-Won
Park Sung-Hyeuk
Lee In-Chul
Lee Sang-Min
Shin In-Sik
Kang Seong-Soo
Moon Chang-Jong
Kim Sung-Ho
Heo Jeong-Doo
Kim Jong-Choon
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Abstract
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1,3-Dichloro-2-propanol (1,3-DCP) is a well-known food contaminant that can be detected during the production of a wide range of foods. We investigated whether garlic oil (GO) has protective effects against 1,3-DCP-induced hepatotixicy and oxidative damage in rats. GO significantly attenuated the 1,3-DCP-induced increase in serum aminotransferase activities. This effect was accompanied by attenuation of the histopahological alterations in liver caused by 1,3-DCP. In 1,3-DCP-treated rats, GO prevented formation of hepatic malondialdehyde and depletion of reduced glutathione content, and promoted hepatic antioxidant enzymes activities. 1,3-DCP caused apoptosis in the liver with increases phosphorylation of mitogen-activated protein kinases (MAPKs); GO significantly attenuated these alterations and suppressed the expression of hepatic cytochrome P450 2E1 (CYP2E1). These results suggest that the protective effects of GO against 1,3-DCP-induced hepatotoxicity involve the ability to induce antioxidant enzymes, block metabolic activation of 1,3-DCP by suppressing CYP2E1 expression, and induce antiapoptotic activity by inhibiting phosphorylation of MAPKs.
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KEYWORD
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Garlic oil, 1,3-Dichloro-2-propanol, Hepatotoxicity, Cytochrome P450 2E1, Mitogen-activated protein kinases
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