|
KMID : 1034820160120030327
|
|
Molecular & Cellular Toxicology
2016 Volume.12 No. 3 p.327 ~ p.336
|
|
|
Association of IL-17A/F polymorphisms with the risk of gastritis and gastric cancer in the Korean population
|
|
Choi Won-Suk
Kim Olga
Yoon Jung-Hwan
Park Yong-Gyu
Nam Suk-Woo
Lee Jung-Young
Park Won-Sang
|
|
|
Abstract
|
|
|
|
We investigated the effects of IL-17A rs2275913 and IL-17F rs763780 polymorphisms on IL-17 expression and the association of these polymorphisms with the risk of gastritis and gastric cancer. IL-17A expression was closely associated with the degree of gastritis in 55 non-neoplastic gastric mucosae and was markedly decreased in subjects carrying A allele. In addition, IL-17F expression was increased in the T allele carriers, but was not associated with gastritis. In 300 gastric cancer patients, the frequency of the rs2275913 A/A genotype was significantly higher in intestinal-type gastric cancer, when compared to that of diffuse-type gastric cancer (P>0.05). There was a significant difference in genotype distribution and allele frequencies of IL-17F rs763780 when comparing gastric cancer patients and 247 healthy controls. These results suggest that the polymorphisms of IL-17F rs763780 and IL-17A rs2275913 are closely associated with susceptibility to the development of gastritis and gastric cancer in the Korean population.
|
|
|
KEYWORD
|
|
|
IL-17A, IL-17F, Polymorphism, Gastritis, Gastric cancer
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|