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KMID : 1034820170130020165
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Molecular & Cellular Toxicology
2017 Volume.13 No. 2 p.165 ~ p.170
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Effect of SKL2001 on the neuronal survival mechanism in Parkinson’s disease
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Choi Pyung-Jun
Oh Sang-Taek
Liew Hyun-Jeong
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Abstract
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The Wnt/β-catenin pathway affects the differentiation of various cell types including mesenchymal stem cells. Previously, we evaluated SKL2001 as a novel agonist of the Wnt/β-catenin pathway. SKL2001 upregulated β-catenin-responsive transcription by increasing the intracellular β-catenin protein level and inhibiting the phosphorylation of β-catenin. Furthermore, SKL2001 disrupted Axin/β-catenin interaction and induced an increase in survivin, an inhibitor of apoptosis. We investigated the effect of SKL2001 on a Parkinson’s disease cell model consisting of SH-SY5Y cells induced by 6-hydroxydopamine. Consequently, we discovered that SKL2001 is effective in promoting neuronal survival and functional recovery by activation of the Wnt/β-catenin signaling pathway.
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KEYWORD
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Canonical Wnt signaling, Parkinson’s disease, β-catenin, Survivin, Nrf2
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