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KMID : 1034820170130020229
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Molecular & Cellular Toxicology
2017 Volume.13 No. 2 p.229 ~ p.238
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miRNA profile of neuroprotection mechanism of echinomycin in Parkinson’s disease
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Kwon Dae-Ho
Liew Hyun-Jeong
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Abstract
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Echinomycin was known as the inhibitor of Hif1a. Discovery of echinomycin make expect for anti-breast cancer drug, but it has only useful in a limited dose in tumor because toxicity was appeared even in normal cells. In here, we developed echinomycin for Parkinson’s disease drug. For evidence, we performed the miRNA array using affymetrix miRNA array, and through the miRNA profiling we predicted the effects of echinomycin in Parkinson’s disease and finally, predicted phenomenon was verified by experiments such as viability assay and signaling checkup. In conclusion, Notch signaling pathway was decelerated and b-catenin stabilization was increased.
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KEYWORD
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Echinomycin, miRNA expression profiling, Parkinson’s disease
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