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KMID : 1034820170130030345
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Molecular & Cellular Toxicology
2017 Volume.13 No. 3 p.345 ~ p.350
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Effect of crotonaldehyde on the induction of COX-2 expression in human endothelial cells
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Lee Seung-Eun
Park Hye-Rim
Kim Hye-Mi
Choi Yeoum
Jin Young-Ho
Park Cheung-Seog
Ahn Hyun-Jong
Cho Jeong-Je
Park Yong-Seek
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Abstract
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Cyclooxygenase-2 (COX-2), an inducible isoform protein, regulates diverse biological actions in vascular pathophysiology. COX-2 is induced in response to numerous stimuli, which results in prostaglandin (PG) production related to inflammation. Crotonaldehyde (CRA) is an extremely toxic α, β-unsaturated aldehyde and a major compound found in cigarette smoke. α, β-Unsaturated aldehyde in cigarette smoke is thought to mediate inflammation and vascular dysfunction. In this study, we evaluated the effect of CRA stimulation on COX-2 expression in human umbilical vein endothelial cells. CRA-stimulated COX-2 induction was accompanied by enhanced p38 phosphorylation and PGE2 generation. However, CRA-induced PGE2 production was reduced by pretreatment with an inhibitor of p38 MAPK. These results demonstrated that in human endothelial cells, CRA-induced COX-2-dependent PGE2 generation was mediated by p38 MAPK, and CRA may play a role in the development of inflammation.
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KEYWORD
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Cyclooxygenase-2, Crotonaldehyde, Cigarette smoke, Endothelial cells, Oxidative stress
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