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KMID : 1034820180140020211
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Molecular & Cellular Toxicology
2018 Volume.14 No. 2 p.211 ~ p.220
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Igongsan reduces testosterone-induced benign prostate hyperplasia by regulating 5α-reductase in rats
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Kang Jong-Wook
Lee Geun-Hyuk
Jung Yun-U
Youn Dong-Hyun
Lim Seo-Na
Park Jin-Bong
Um Jae-Young
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Abstract
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Backgrounds: Igongsan (IGS) is a traditional Korean herbal medication composed of five different herbs; Citri Unshius Pericarpium, Poria Sclerotium, Glycyrrhizae Radix et Rhizoma, Atractylodis Rhizoma Alba, and Ginseng Radix. In this study, we evaluated the effect of IGS on benign prostatic hyperplasia (BPH), a disease resulting from a noncancerous size increase of the prostate which is common in aging men.
Methods: We induced BPH by a 4-week daily injection of testosterone propionate and investigated the effects IGS on BPH. After pre-treatment, the rats were divided into four groups and treated by each drugs for 4 weeks. Histological alteration was observed by hematoxylin and eosin (H&E) staining. Type-2 5α-reductase (5AR-2), androgen receptor (AR), estrogen receptor-α (ERα) and prostate specific antigen (PSA) were confirmed by western blot analysis and immunohistochemistry staining.
Results: IGS reduced the enlarged prostate and prostatic index, while the epithelium thickness and enlarged lumen area returned to their normal state in BPH-induced rats. In particular, 5AR-2, which is a major target for BPH medication, was inhibited by IGS. IGS also regulated the factors including AR and ERα to interact with 5AR-2. Consequently, PSA, a major diagnostic marker for BPH, was suppressed by IGS treatment.
Conclusion: Based on our findings, this study shows that IG S can alleviate BPH by regulating 5AR, suggesting its potential as a new, effective medication for BPH treatment.
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KEYWORD
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Benign prostate hyperplasia, Igongsan, Type-2 5α-reductase, Androgen receptor, Estrogen receptor α, Prostate specific antigen
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