KMID : 1034820180140020241
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Molecular & Cellular Toxicology 2018 Volume.14 No. 2 p.241 ~ p.245
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Diethylamino-curcumin mimic with trizolyl benzene enhances TRAIL-mediated cell death on human glioblastoma cells
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Ahn Yong-Chel
Lee Seok-Joon Park Cheon-Soo Jang Hyuk-Jai Lee Ji-Hwan Park Byong-Gon Park Yoon-Sun Shin Woon-Seob Kwon Dae-Ho
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Abstract
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Backgrounds: Glioblastoma multiforme is one of the most aggressive human malignant brain tumors. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is known as the death ligand, which induces preferential apoptosis of transformed cancer cells. In this study, we demonstrated that the newly synthesized diethylamino-curcumin mimic with trizolyl benzene (YM-4) enhances cytotoxicity in combination with TRAIL in human glioblastoma cells.
Methods: We synthesized diethylamino-curcumin mimic with trizolyl benzene (YM-4) and investigated possible apoptotic cell signaling by co-treatment with YM-4 and TRAIL on human glioblastoma cells.
Results: Caspase-8, 9, and 3 and poly (ADP-ribose) polymerase were more efficiently cleaved with cotreatment of YM-4 and TRAIL than treatment with each alone in human glioblastoma cells. Co-treatment with YM-4 and TRAIL significantly increased the expression of Bax and Smac/Diablo and also inhibited the expression of the X-linked inhibitor of apoptosis protein and Survivin in human glioblastoma cells.
Conclusion: These results demonstrated that YM-4 can be an anticancer candidate that can be effective on human glioblastoma cells in combination with TRAIL.
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KEYWORD
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Curcumin mimic, TRAIL, Apoptosis, Human glioblastoma cells
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