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KMID : 1034820180140030303
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Molecular & Cellular Toxicology
2018 Volume.14 No. 3 p.303 ~ p.313
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Differentially expressed genes between intestinal- and diffuse-type gastric cancers
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Kim Olga
Yoon Jung-Hwan
Ashktorab Hassan
Smoot Duane T.
Nam Suk-Woo
Lee Jung-Young
Park Won-Sang
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Abstract
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Backgrounds: The two main types of gastric cancer, intestinal and diffuse, have different etiologies and pathogeneses, indicating different mechanisms of histogenesis and carcinogenesis that remain poorly understood.
Methods: The expression and correlation patterns of 13 development-, differentiation-, proliferation-, and invasion- related genes were compared between 23 diffuseand 27 intestinal-type gastric cancers by quantitative RT-PCR. In addition, the most representative results were confirmed by western blot analysis and methylation analysis was also performed in the two gastric cancer types using methylation-specific PCR.
Results: Seven genes, including SOX2, Muc5ac, CDH1, Muc4, TFF1, FGF7, and MMP10, with differential expression and correlation patterns between the two histological gastric cancer types were identified. Furthermore, Muc5ac, TFF1, MMP10, CDH1, and CDX2 expression levels were linked to DNA methylation status.
Conclusion: These data provide insights into type-specific gastric carcinogenesis, suggesting new approaches for a more profound investigation of the pathologic events that drive intestinal- and diffuse-type gastric cancer.
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KEYWORD
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Differentially expressed genes (DEG s), Diffuse-type gastric cancer, Intestinal-type gastric cancer, Methylation, Carcinogenesis
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