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KMID : 1034820200160020129
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Molecular & Cellular Toxicology
2020 Volume.16 No. 2 p.129 ~ p.137
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Particulate matter (PM)2.5 affects keratinocytes via endoplasmic reticulum (ER) stress-mediated suppression of apoptosis
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Kim J.-H.
Son J.-W.
Kim J.
Kim M.-G.
Jeong S.-H.
Park T.-J.
Son S.-W.
Ryu H.-J.
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Abstract
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Background: Particulate matter (PM)2.5 is a concern for public health nowadays. Although few studies have reported the skin diseases associated with PM2.5, its effects on keratinocytes have yet to be elucidated.
Objective: The goal of this experiment was to analyze and identify the changes of gene expression in PM2.5-treated keratinocytes using RNA-sequencing (RNA-Seq) data.
Results: PM2.5-treated keratinocytes exhibited changes in cell cycle-related genes as well as genes involved in DNA replication, endoplasmic reticulum (ER) stress, intrinsic apoptosis, and immune response. A total of 669 genes showed changes in gene expression in PM2.5-treated keratinocytes, including 304 upregulated and 365 downregulated genes.
Conclusion: Unlike other studies investigating skin disorders associated with PM2.5, our study found the mechanism of apoptosis suppression in keratinocytes. The findings may provide a novel insight into the management of chronic skin diseases in relation to PM2.5.
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KEYWORD
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Particulate matter (PM), Psoriasis, Cell proliferation, Endoplasmic reticulum (ER) stress, Apoptosis
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