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KMID : 1034820200160040431
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Molecular & Cellular Toxicology
2020 Volume.16 No. 4 p.431 ~ p.439
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Capture and toxicity assessment of Ag citrate nanoparticles using jellyfish extract
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Ha Ji-Won
Kim Eun-A
Lee Bong-Gu
Yeo Min-Kyeong
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Abstract
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Backgrounds: In this study, Jellyfish extract at immunity reaction (JEI) captured Ag citrate nanoparticles (Ag citrate NPs) and reduce toxicity was investigated.
Methods: JEI obtained from Aurelia aurita was used to assess the capture of Ag citrate NPs (10 mg/L, 2 mg/L) during 24 h, and the toxicity of JEI was assessed using a human cell line BEAS-2B.
Results: JEI was to reduce Ag citrate NPs in water by 34.55% (10 mg/L) after 1 h and by 40.62?~?41% (2 mg/L, 10 mg/L) after 24 h. When the BEAS-2B was exposed to 2 mg/L of Ag citrate NPs mixed with JEI showed increase 33.97% survival than 2 mg/L of Ag citrate NPs (0%). Furthermore, the apoptosis-related genes (p53, Bcl2, and Bax) showed no significant difference in expression upon exposure to JEI, compared to the control.
Conclusion: JEI is to capture Ag citrate NPs and reduce its nano-toxicity. Therefore, such ability of JEI is likely to prove useful in the control of AgNPs flowing into the aquatic ecosystem.
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KEYWORD
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Ag citrate nanoparticle, BEAS-2B cell line, Immunity reaction, Jellyfish extract, Nano-toxicity
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