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KMID : 1034820200160040469
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Molecular & Cellular Toxicology
2020 Volume.16 No. 4 p.469 ~ p.476
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Effects of α-mangostin on embryonic development and liver development in zebrafish
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Pimtong Wittaya
Kitipaspallop Wannakarn
Chun Hang-Suk
Kim Woo-Keun
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Abstract
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Background: Alpha-mangostin has potential as a chemopreventive agent but there is little information on its toxicological profile and developmental toxicity.
Objective: We evaluated the effects of α-mangostin on embryonic development and hepatogenesis in zebrafish.
Result: Exposure of embryos to 0.25?4 μM α-mangostin from 4?120 h post-fertilization (hpf) caused mortality of embryos with LC50 1.48?±?0.29 μM. The compound also caused deformities, including head malformation, pericardial oedema, absence of swim bladder, yolk oedema, and bent tail. Exposure of zebrafish embryos to α-mangostin during early hepatogenesis (16?72 hpf) decreased the transcript expression levels of liver fatty acid-binding protein 10a (Fabp10a), but increased gene markers of inflammation, oxidative stress, and apoptosis. In Fabp10a:DsRed transgenic zebrafish, the intensity and the area of fluorescence in the liver of the treated group were decreased (non-significantly) relative to controls.
Conclusion: These effects were more marked during early hepatogenesis (16?72 hpf) than during post-hepatogenesis (72?120 hpf).
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KEYWORD
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α-Mangostin, Xanthone, Zebrafish, Hepatogenesis, Toxicity
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