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KMID : 1034820210170020195
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Molecular & Cellular Toxicology
2021 Volume.17 No. 2 p.195 ~ p.200
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Urban particulate matters induce EGR-1 expression in keratinocytes which correlates with the severity of psoriasis
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Park Tae-Jun
Oh Ha-Neul
Kim Min-Gyu
Kim Jae-Hyung
Kim Hee-Joo
Son Sang-Wook
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Abstract
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Background: Early growth response protein (Egr)-1 is a transcription factor important for cell growth and initiation of immune responses. It is significantly up-regulated in psoriatic skin.
Objective: We evaluated the differential expression of Egr-1 in skin lesions of plaque psoriasis and its correlation with the severity of psoriasis. We also used in vitro methods in normal keratinocytes to analyze if urban particulate matter influences Egr-1 expression.
Results: Egr-1 was significantly up-regulated in the psoriatic skin, specifically in the stratum basale. Its expression was positively correlated with the severity of psoriasis (ρ?=?0.497, P?=?0.013). It was also significantly up-regulated in keratinocytes with exposure to urban particulate matters under in vitro condition.
Conclusion: Up-regulated expression of Egr-1 in the epidermis suggests that it plays a role in psoriasis by accelerating epidermal cell replication, to which could be attributed by urban particulate matter.
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KEYWORD
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Early growth response protein 1, Psoriasis, Urban particulate matter
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