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KMID : 1034820210170020201
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Molecular & Cellular Toxicology
2021 Volume.17 No. 2 p.201 ~ p.212
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KIF11 inhibition decreases cytopathogenesis and replication of influenza A virus
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Kim Dong-In
Kang Ji-Hun
Kim Eui-Ho
Seo Young-Jin
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Abstract
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Background: Seasonal flu is an infectious disease of the respiratory tract caused by influenza viruses. The development of anti-influenza drugs has significantly reduced the threat from the influenza virus; however, frequent mutations of this negative RNA virus result in antiviral-resistant strains, and constantly intimidate the human race. Thus, identifying novel therapeutic targets for the prevention and treatment of influenza virus infections is critical.
Objective: We aimed to determine whether the kinesin superfamily protein 11 (KIF11) inhibitors, monastrol and K858, inhibit viral cytopathogenesis and influenza A virus (IAV) replication.
Result: When MDCK or HEK293 cells were treated with monastrol and K858 that did not induce significant cytotoxicity, IAV-induced cytopathic effect was attenuated significantly. Furthermore, these inhibitors effectively suppressed the production of viral RNA, proteins, and infectious viral particles.
Conclusion: Inhibition of KIF11 activity effectively attenuates virus-mediated cytopathic effect and suppresses viral replication. Hence, KIF11 is a potential therapeutic target against the influenza virus.
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KEYWORD
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KIF11, Influenza A virus, Viral cytopathogenesis, Anti-viral drug
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