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KMID : 1034820210170020213
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Molecular & Cellular Toxicology
2021 Volume.17 No. 2 p.213 ~ p.220
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An integrated mRNA?microRNA regulatory network identified INHBA and has-miR-135a-5p as predictors of gastric cancer recurrence
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Sohn Sung-Hwa
Sul Hee-Jung
Choi Yeon-Song
Lee Se-Min
Kim Bum-Jun
Kim Hyeong-Su
Koh Young-Ho
Zang Dae-Young
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Abstract
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Backgrounds: Gastric cancer (GC), a prevalent malignancy in Eastern Asia, is associated with aberrant transcriptional regulation.
Objective: Here, we evaluated the mRNA and microRNA transcriptomes in patients with gastric cancer to gain insight into the molecular underpinnings of this disease.
Results: We observed upregulation of inhibin βA (INHBA), CDC7, SULF1, COL11A1, KIAA1199, and CLDN1 transcripts in gastric cancer and showed that INHBA upregulation was associated with cancer recurrence. Expression of has-miR-135a-5p was significantly lower in gastric cancer tissues compared with matched normal tissues and was inversely associated with INHBA expression.
Conclusion: Our findings suggest that INHBA and has-miR-135a-5p expression serve as therapeutic markers of gastric cancer recurrence.
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KEYWORD
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Gastric cancer, Transcriptome analysis, RNA sequencing, Has-miR-135a-5p, INHB
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