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KMID : 1034820210170030257
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Molecular & Cellular Toxicology
2021 Volume.17 No. 3 p.257 ~ p.266
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Kaempferol attenuates spinal cord injury by interfering inflammatory and oxidative stress by targeting the p53 protein: a molecular docking analysis
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Chen Lu
Cao Kai
Gu Yurong
Luo Chao
Mao Wei
Zhou Weijun
Zhu Jinwei
Zhang Huying
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Abstract
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Background: Kaempferol (KMF) is a flavone reported to have anti-oxidant and anti-inflammatory activity.
Objective: The present study screened the effect of KMF in the animal model of spinal cord injury (SCI).
Results: KMF caused a significant inhibition of spinal cord injury mediated oxidative stress and also suppressed the inflammatory reactions. The treatment of KMF also inhibited the levels of p53, TGF-β1 and COX-2 whereas a significant elevation in Bcl-2/Bax ratio was observed after the rats were treated with KMF. The in silico docking analysis suggested potential binding of KMF having lower energy with p53 confirming the potential target of KMF.
Conclusion: The treatment of KMF exerted neuroprotective effect by improving the anti-oxidant status and inflammatory response. The significant spinal cord injury protective effect of KMF in rats was attributed by targeting p53 and Bcl-2/Bax ratio.
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KEYWORD
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Spinal cord injury, Kaempferol, P53, Oxidative stress, Inflammatory response
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