|
KMID : 1034820210170030297
|
|
Molecular & Cellular Toxicology
2021 Volume.17 No. 3 p.297 ~ p.304
|
|
|
Dapk1 promoted inflammation of infantile pneumonia by p38MAPK/NF-κB signaling pathway
|
|
Zhang Wenbo
|
|
|
Abstract
|
|
|
Background: The present study was designed to investigate the function of death-associated protein kinase 1 (DAPK1) in infantile pneumonia and explore the potential mechanism of the actions.
Objective: Male C57BL/6 mice were injected with 2 mg/kg of LPS for the mice model of infantile pneumonia. A549 cells were treated with 100 ng/ml of LPS for vitro model of infantile pneumonia. Dapk1 mRNA and protein expressions in 6, 12 or 24 h after induction model of mice.
Results: Dapk1 gene increased inflammation in vitro model through activation of p38MAPK-mediated NF-κB expression. The inhibition of p38MAPK or NF-κB reduced the pro-inflammation effects of DAPK1 in infantile pneumonia.
Conclusions: Our study demonstrates that Dapk1 promoted inflammation of infantile pneumonia by p38MAPK/NF-κB signaling pathway, may be achieved inflammation by activation of p38MAPK/NF-κB signaling pathway.
|
|
|
KEYWORD
|
|
|
Dapk1, P38MAPK, NF-κB, Infantile pneumonia
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|