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KMID : 1034820220180010001
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Molecular & Cellular Toxicology
2022 Volume.18 No. 1 p.1 ~ p.8
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Modifications of mRNA vaccine structural elements for improving mRNA stability and translation efficiency
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Kim Sun-Chang
Sekhon Simranjeet Singh
Shin Woo-Ri
Ahn Gna
Cho Byung-Kwan
Ahn Ji-Young
Kim Yang-Hoon
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Abstract
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Background: mRNA vaccines hold great potential as therapeutic techniques against viral infections due to their efficacy, safety, and large-scale production. mRNA vaccines offer flexibility in development as any protein can be produced from mRNA without altering the production or application process.
Objective: This review highlights the iterative optimization of mRNA vaccine structural elements that impact the type, specificity, and intensity of immune responses leading to higher translational potency and intracellular stability.
Results: Modifying the mRNA structural elements particularly the 5′ cap, 5′-and 3′-untranslated regions (UTRs), the coding region, and polyadenylation tail help reduce the excessive mRNA immunogenicity and consistently improve its intracellular stability and translational efficiency.
Conclusion: Further studies regarding mRNA-structural elements and their optimization are needed to create new opportunities for engineering mRNA vaccines.
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KEYWORD
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mRNA vaccine, 5′ Cap, 5′-and 3′-UTRs, Poly(A) tail, structural modification
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FullTexts / Linksout information
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