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KMID : 1034820220180010023
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Molecular & Cellular Toxicology
2022 Volume.18 No. 1 p.23 ~ p.30
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Fatty acid-binding protein 5 activates cyclooxygenase-2 and promotes hypoxic injury in LO2 cells
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Pan Long
Pang Yihan
Xiao Heng
Deng Xin
Chen Qingsong
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Abstract
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Background: Hepatic hypoxia always results in liver inflammation and dysfunction. Fatty acid-binding protein 5 (FABP5) has been reported as a hypoxia-inducible gene and a regulator of inflammatory reaction.
Objective: To evaluate the effects of FABP5 on hypoxic liver injury and its potential mechanisms.
Results: FABP5 was hypoxia-inducible expression in liver tissues and LO2 cells. The expression levels of IL6 and TNFα were upregulated with the increasing expression of FABP5 in LO2 cells. Downregulation of FABP5 expression decreased the expression levels of ALT, AST and increased cell viability of hypoxic LO2 cells. Downregulation of FABP5 expression inhibited the cyclooxygenase-2/prostaglandin E2 (COX-2/PGE2) pathway and decreased inflammatory reaction in hypoxic LO2 cells.
Conclusions: FABP5 was shown to activate COX-2/PGE2 pathway and promote hypoxic injury in LO2 cells. FABP5 may be a potential target for the treatment of hypoxic liver injury.
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KEYWORD
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Fatty acid-binding protein 5, Liver, Hypoxic injury, Cyclooxygenase-2
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