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KMID : 1034820220180020185
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Molecular & Cellular Toxicology
2022 Volume.18 No. 2 p.185 ~ p.191
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Knockdown of hsa_circ_0001964 inhibits hepatocellular carcinoma cell proliferation by inactivating PI3K/AKT signaling pathway
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Li Liao
Miao Changfeng
Peng Shayong
Jiang Yu
Lu Xinchun
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Abstract
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Background: Circular RNAs (CircRNAs) play vital roles in the pathogenesis of hepatocellular carcinoma (HCC). However, the exact role and detailed mechanism of hsa_circ_0001964 during HCC carcinogenesis remains unknown.
Objective: To explore the expression, role and mechanism of hsa_circ_0001964 in HCC.
Result: The results indicated that the mRNA expression of hsa_circ_0001964 was upregulated in HCC cell lines and tissues, respectively, and hsa_circ_0001964 knockdown inhibited HCC cell proliferation in vitro. Western blot analysis showed that hsa_circ_0001964 knockdown suppressed the activation of the PI3K/AKT signaling pathway and its downstream factors (including c-Jun, c-Myc, and CCND1).
Conclusion: The results of the present study suggested that hsa_circ_0001964 may correlate with HBV infection, and it promotes HCC carcinogenesis via the PI3K/AKT signaling pathway. The findings of the present study provide important insights into the molecular mechanisms of HCC initiation, which may help to develop new treatment strategies against HCC.
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KEYWORD
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hsa_circ_0001964, Hepatocellular carcinoma, PI3K/AKT, Carcinogenesis
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