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KMID : 1034820220180030329
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Molecular & Cellular Toxicology
2022 Volume.18 No. 3 p.329 ~ p.337
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Pratensein glycoside attenuates respiratory syncytial virus infection-induced oxidative and inflammatory injury via TGF-β signaling pathway
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Zhang Qiong
Li Si
Huang Qiong
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Abstract
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Background: Respiratory syncytial virus (RSV)-induced oxidative stress and inflammation are the leading causes of many severe diseases, especially in infants and children. Although many studies focused on the mechanism during RSV infection, an effective therapy is still urgently needed.
Objectives: In our study, we examined the function of pratensein glycoside (PG) in the progression of RSV-induced infection in vitro.
Results: PG treatment significantly inhibited RSV-induced oxidative stress and inflammation in a dose-dependent manner. We found that 40 μM of PG had no significant cytotoxicity and exerted an anti-viral effect. RSV infection led to the activation of the TGF-β signaling pathway, which in turn promoted RSV infection. We hyperactivated the TGF-β signaling pathway by TGF-β and found that PG treatment can repress the pro-inflammation effect of TGF-β, suggesting that PG inhibits RSV infection through inhibiting TGF-β signaling pathway.
Conclusions: PG attenuated RSV infection-induced oxidative stress and inflammation through inhibiting the TGF-β signaling pathway. This study provides evidence for the application of traditional Chinese herbal medicine in the treatment of viral infection.
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KEYWORD
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Respiratory syncytial virus, Pratensein glycoside, Pneumonia, TGF-β
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