|
KMID : 1034820220180040531
|
|
Molecular & Cellular Toxicology
2022 Volume.18 No. 4 p.531 ~ p.538
|
|
|
Acute effects of 4-EA-NBOMe, 3, 4-DCMP, LY-2183240 and AB-CHFUPYCA on the excitability of rat cortical primary cultured neurons
|
|
Oh Hyun-A
Lee Jong-Hwa
Woo Dong-Ho
|
|
|
Abstract
|
|
|
Background: Various methods to evaluate the effect of new psychoactive substances (NPSs) on the central nervous system (CNS) are available, but they are not sufficient. There is an urgent need for a method to measure and analyze the effect of NPS on the CNS for scientific research.
Objectives: We investigated whether seven psychoactive substances (PSs) affect the excitability of rat cortical culture neurons by counting the number of action potentials (APs) in current clamp modes.
Results: Incubation with Meth, THC, LY2183240 and AB-CHFUPYCA for 2 min increased the number of APs; in contrast, incubation with 4-EA-NBOMe and CMP reduced the number of APs. Cocaine did not show any effects on the number of APs.
Conclusion: Acute treatment with PSs changed neural excitability as evidenced by the number of APs. Our data provide scientific evidence that acute PS exposure can affect the CNS.
|
|
|
KEYWORD
|
|
|
New psychoactive substance, Meth, 4-EA-NBOMe, 3, 4-DCMP, THC, LY-2183240, AB-CHFUPYCA, Cocaine, Rat primary cortical neurons
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|