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KMID : 1034820220180040599
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Molecular & Cellular Toxicology
2022 Volume.18 No. 4 p.599 ~ p.604
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Knockdown of RBBP6 enhances radiosensitivity of gastric cancer cells through p53 pathway
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Bi Meng
Sun Jingzhi
Wang Fengtong
Li Shenchi
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Abstract
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Background: Radiotherapy is regarded as commonly standard-of-care for the treatment of patients with gastric cancer. However, the resistance to radiotherapy impedes the efficiency of the therapy. Retinoblastoma-binding protein 6 (RBBP6), an independent prognostic factor of gastric cancer, contributed to the cancer progression. RBBP6 was associated with chemoresistance and radioresistance of colorectal cancer. However, the effect of RBBP6 on radiosensitivity of gastric cancer has not been investigated yet.
Objective: To investigate the effect of RBBP6 on radiosensitivity of gastric cancer.
Results: Knockdown of RBBP6 decreased the cell viability of gastric cancer cells after the irradiation. The cell proliferation of irradiation-treated gastric cancer cells was also suppressed by silence of RBBP6. Moreover, interference of RBBP6 promoted cell apoptosis of gastric cancer cells, and significantly aggravated irradiation-induced cell apoptosis (p?
Conclusion: RBBP6 silence was considered to be a potential sensitizer for the radiotherapy of gastric cancer through activation of p53 signaling.
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KEYWORD
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RBBP6, Radiosensitivity, Gastric cancer, p53 pathway
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