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KMID : 1034820230190030415
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Molecular & Cellular Toxicology
2023 Volume.19 No. 3 p.415 ~ p.424
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MiR-601 inhibited small cell lung cancer progression by modulating SIRT1
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Hao Ding
Chenhu Gong
Zhihong Zhang
Hui Xu
Chunping Ma
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Abstract
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Background : Dysfunction of microRNAs (miRNAs) contribute to small cell lung cancer (SCLC) progression. Accumulating evidence indicated miR-601, acted as a tumor suppressor gene, has shown an altered expression pattern in multiple cancers. However, little was known about in terms of the function of miR-601 during SCLC progression.
Objective : Our project intended to illustrate the functions of miR-601 during the development and metastasis of SCLC.
Results : We found a decreased expression of miR-601 in SCLC tumor tissues and cell lines. Moreover, functional studies suggested that miR-601 overexpression resulted in a reduced cell growth and induced apoptosis of SCLC cells. Notably, sirtuin 1 (SIRT1) was identified as a putative target of miR-601. MiR-601 suppressed SIRT1 expression via interacting with the 3′-untranslated region (UTR) of SIRT1 in SCLC cells. Also, SIRT1 expression was negatively associated with that of miR-601 in SCLC tissues. The restoration of SIRT1 alleviated the inhibitory effect of miR-601 on SCLC progression.
Conclusion : Our data documented the tumor-suppressive function of miR-601 in SCLC via targeting SIRT1, suggesting miR-601 as a new potential therapeutic approach for SCLC treatment.
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KEYWORD
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Small cell lung cancer, miR-601, SIRT1
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