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KMID : 1034820230190030463
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Molecular & Cellular Toxicology
2023 Volume.19 No. 3 p.463 ~ p.472
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SSX2IP as a novel prognosis biomarker plays an important role in the development of breast cancer
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Xianfu Liu
Min Tao
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Abstract
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Background : SSX2IP plays a critical role in tumorigenesis and its overexpression has been found in many types of cancer, such as an associated antigen in acute myeloid leukemia and breast cancer. However, the pathophysiological role of SSX2IP in BC has not been evaluated.
Objective : To investigate that SSX2IP gene plays an important role in the development of breast cancer, which can be used as a diagnostic marker for breast cancer.
Results : SSX2IP are detected in BC in this study, the result shown that SSX2IP mRNA and protein were upregulated in both human breast cancer samples and cell lines. With the depletion of SSX2IP, the results demonstrated the BT549 cell activity, proliferation, migratory and invasive, clone formation abilities were inhibited, and the cell apoptosis increased.
Conclusion : These data indicated that SSX2IP promotes tumor progression in BC, include cell activity, proliferation, migratory and invasive, clone formation abilities were inhibited, and the cell apoptosis increased. This work further suggest that SSX2IP could be used to be a potential therapeutic targets in BC.
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KEYWORD
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Breast cancer, SSX2IP, Cell activity, Migration, Invasive, Apoptosis
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