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KMID : 1034820230190030491
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Molecular & Cellular Toxicology
2023 Volume.19 No. 3 p.491 ~ p.498
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FBXO22 promotes cell proliferation and inhibits autophagy in HPV-associated cervical cancer by inactivating the LKB1/AMPK pathway
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Fuxian Gao
Chunxiao Wang
Jianghai Ji
Wenjuan Li
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Abstract
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Background : Cervix cancer (CC) is the most common gynecological malignancy and the leading cause of morbidity in women around the world.
Objectives : In this research, the effect of FBXO22 on HPV-associated CC was evaluated.
Results : The results first illuminated that FBXO22 was highly expressed in HPV+ CC patients. FBXO22 knockdown inhibited the proliferation of HPV+ CC cells, and promoted autophagy in HPV+ CC cells. Finally, FBXO22 regulates the LKB1/AMPK pathway.
Conclusion : This research hinted that FBXO22 promotes cell proliferation and inhibits autophagy in HPV-associated CC by inactivating the LKB1/AMPK pathway.
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KEYWORD
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FBXO22, LKB1, AMPK, Proliferation, Autophagy, Cervical cancer
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