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KMID : 1034820230190030531
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Molecular & Cellular Toxicology
2023 Volume.19 No. 3 p.531 ~ p.538
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KLF9 promotes autophagy and apoptosis in T-cell acute lymphoblastic leukemia cells by inhibiting AKT/mTOR signaling pathway
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Bahn Geon-Ho
Shaolong He
Chenhuan Xiang
Shaoli Zhang
Xinyue Chen
Xinyi Lu
Qiong Yao
Liping Yang
Liangming Ma
Weiwei Tian
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Abstract
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Background : T-cell acute lymphoblastic leukemia (T-ALL) is considered a malignant tumor with a high mortality rate. To combat this disease, exploring the mechanism of T-ALL progression is urgently needed. Kruppel-like factors (KLFs) are known as the transcription factors and mediate series of biological processes. KLF9 is a member of the KLF family which could serve as a tumor suppressor gene in most solid tumors. GEO Database analysis showed that KLF9 expression in normal T cells was higher than T-ALL cell lines and patients. However, the possible role of KLF9 in T-ALL progression is still unclear.
Objective : To uncover the possible effects of Kruppel-like transcription factor 9 (KLF9) on the progression of T-Acute lymphoblastic leukemia (T-ALL).
Results : The expression of KLF9 was low in human T-ALL cells. KLF9 suppressed the viability of T-ALL cells. In addition, KLF9 stimulated the apoptosis as well as autophagy of T-ALL cells. Mechanically, KLF9 suppressed AKT/mTOR pathway in T-ALL cells.
Conclusion : KLF9 suppressed viability and promoted autophagy as well as apoptosis in T-ALL cells by inhibiting AKT/mTOR pathway.
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KEYWORD
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Kruppel-like transcription factor 9 (KLF9), T-cell acute lymphoblastic leukemia (T-ALL), Apoptosis, Autophagy, AKT/mTOR pathway
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