|
KMID : 1034820230190030579
|
|
Molecular & Cellular Toxicology
2023 Volume.19 No. 3 p.579 ~ p.590
|
|
|
Circular RNA circ_0000877 serves as a miR-671-5p sponge to regulate diffuse large B-cell lymphoma development via HK2
|
|
Weilun Zhou
Cuiping Wu
Jiao Wang
|
|
|
Abstract
|
|
|
Background : Emerging evidence has revealed that circular RNAs (circRNAs) are critical regulators for the development of various tumors, containing diffuse large B-cell lymphoma (DLBCL). CircRNA microarray analysis suggested that circ_0000877 was freakishly increased in DLBCL tissues.
Objective : This study is designed to explore the role and mechanism of circ_0000877 on DLBCL development.
Results : Circ_0000877 and HK2 were increased, and miR-671-5p was reduced in DLBCL tissues and cell lines. Also, circ_0000877 silencing hindered DLBCL cell proliferation and glycolysis, and induced apoptosis in vitro. Mechanically, circ_0000877 functioned as a sponge of miR-671-5p, and circ_0000877 knockdown-mediated DLBCL cell development inhibition was relieved by miR-671-5p downregulation. Moreover, HK2 acted as a direct target gene of miR-671-5p, and enhanced HK2 might abolish the impact of miR-671-5p on DLBCL cell progression.
Conclusion : Circ_0000877 silencing mitigated DLBCL cell malignant biological behavior partly via miR-671-5p/HK2 axis, referring to circ_0000877 as an underlying prognostic biomarker. These data provided a promising strategy for treating DLBCL malignancies.
|
|
|
KEYWORD
|
|
|
Circ_0000877, miR-671-5p, HK2, Lymphoma
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|