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KMID : 1034920080010010001
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Journal Of Oriental Pharmacy
2008 Volume.1 No. 1 p.1 ~ p.5
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Effect of Jak-Yak Tang water extract on expression of cytokin and chemokine
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Oh You-Chang
Kwon Dong-Yeul
Kang Ok-Hwa
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Abstract
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Objectives: The purpose of this study was to investigate the anti-inflammatory effects of extract from Jak-Yak Tang (JYT) on the THP-1 cell and HMC-1 cell.
Method: To evaluate of anti-inflammatory of JYT, we examined cytokines production in lipopolysacchride (LPS)-induced THP-1 cell and A23187, PMA-induced HMC-1 cell.
Result: Extract of JYT inhibit LPS-induced interleukin (IL)-8 production in human monocyte THP-1 cells. Extract of JYT inhibit A23187, PMA-induced IL-8, tumor necrosis factor- (INF-) production in HMC-1 cells.
Conclusion: NT down-regulated LPS-induced IL-8 production and A23187, PMA-induced IL-8, TNF- production, which may be provide a clinical basis for anti-inflammatory properities of JYT.
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KEYWORD
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Jak-Yak Tang (JYT), anti-inflammation, interleukin (IL)-8, tumor necrosis factor- (TNF-, )
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