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KMID : 1034920080010010007
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Journal Of Oriental Pharmacy
2008 Volume.1 No. 1 p.7 ~ p.11
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Inhibitory effect of Hwang lyun tang water extract on inflammatory mediators
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Chae Hee-Sung
Kwon Dong-Yeul
Kang Ok-Hwa
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Abstract
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The purpose of this study was to investigate the anti-inflammatory effects of extract from Hwang lyun tang (HLT) on the THP-1 cell and HMC-1 cell. To evaluate of anti-inflammatory of HLT, we examined cytokines production in lipopolysacchride (LPS)-induced THP-1 cell and A23187, PMA-induced HMC-1 cell. Extract of HLT inhibit LPS-induced interleukin (IL)-8 production in human monocyte THP-1 cells. Extract of HLT inhibit A23187, PMA-induced IL-8, tumor necrosis factor- (INF-) production in HMC-1 cells. HLT down-regulated LPS-induced IL-8 production and A23187, PMA-induced IL-8, TNF- production, which may be provide a clinical basis for anti-inflammatory properities of HLT.
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KEYWORD
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Hwang lyun tang (HLT), anti-inflammation, interleukin (IL)-8, tumor necrosis factor- (TNF-, )
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