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KMID : 1034920080010010013
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Journal Of Oriental Pharmacy
2008 Volume.1 No. 1 p.13 ~ p.18
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Inhibitory effects of Polygoni cuspidati rhizoma on Mast Cell-Mediated Anaphylactic Reaction
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Kang Tae-Hee
Jeong Hyun-Ja
Jeung Eun-Suk
Choi In-Young
Um Jea-Young
Hong Seung-Heon
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Abstract
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Polygoni cuspidati Rhizoma (PCRH) has been used in treatment of menoxenia, skin burn, gallstone, hepatitis, hyperlipidaemia, favus athlete’s foot, supperative dermatitis and inflammation. However, its effect in experimental models remains unknown. In this present study, the effect of PCRH for stability on mast cell was analyzed. Two g/kg PCRH inhibited the compound 48/80-induced anaphylaxis by 75%. In addition, PCRH inhibited the tumor necrosis factor- and interleukin-8 secretion as compared with the phorbol 12-myristate 13-acetate plus calcium ionophore A23187 stimulated human mast cell line, HMC-1 cells. These results suggested PCRH may inhibit mast cell-mediated anaphylactic reaction.
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KEYWORD
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Polygoni cuspidati Rhizoma, Mast cell, Anaphylaxis, TNF-, IL-8
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