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KMID : 1034920100030010035
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Journal Of Oriental Pharmacy
2010 Volume.3 No. 1 p.35 ~ p.41
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Isolation and Structure Determination of Coumarin Derivatives from the Roots of Angelica dahurica
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Kim Ji-Yeon
Son Jong-Keun
Song Dong-Keun
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Abstract
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From the roots of Angelica dahurica Bentham et Hooker (Umbelliferae), three known coumarin derivatives have been isolated and identified as 8-(2-hydroxy-3-methoxy-3-methylbutyloxy) psoralen, 5,8-di(2,3-dihydroxy-3-methylbutyloxy) psoralen, 9-[3-(β-D-glucopyranosyloxy)-2-hydroxy-3-methylbutoxy]-7H-furo[3,2-g][1]benzopyran-7-one. This is the first report of the occurrence of these compounds in this plant. These three compounds were tested for activity in septic shock model. Among these compounds, 2 showed relatively strong preventive activity against septic shock.
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KEYWORD
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Angelica dahurica, Umbelliferae, Coumarin derivatives, Septic shock
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