KMID : 1035620130010040400
|
|
Allergy Asthma & Respiratory Disease 2013 Volume.1 No. 4 p.400 ~ p.404
|
|
Dapsone-induced drug reaction with eosinophilia and systemic symptoms syndrome, misdiagnosed as lymphoma
|
|
Shin Bo-Mi
Park So-Young Yoon Sun-Young Kim Tae-Bum Cho Yoo-Sook Moon Hee-Bom Kwon Hyouk-Soo Shin Eun-Hye Yang Young-Joo Cho Hyung-Jin Jang Il-Young Kang Dang-Uk
|
|
Abstract
|
|
|
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction with systemic manifestations. Dapsone is known to be useful for treatment of leprosy and various dermatologic conditions. We report a patient with prurigo pigmentosa who developed DRESS syndrome after dapsone treatment. She presented with lymphadenopathy, fever, eosinophilia, skin rash, and elevated liver enzymes. Initial lymph node and skin biopsy was suggestive of peripheral T-cell lymphoma. Initially, she was treated with chemotherapy. A week later after complete remission of skin symptoms, new skin lesions recurred. TCR-gene rearrangement was examined to show negative results and she was diagnosed as dapsone induced DRESS syndrome. This case emphasizes the importance of differential diagnosis of lymphoma and DRESS syndrome.
|
|
KEYWORD
|
|
DRESS syndrome, Dapsone, Pseudolymphoma, Drug hypersensitivity
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|