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KMID : 1036020220110010039
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지질.동맥경화학회지
2022 Volume.11 No. 1 p.39 ~ p.54
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Individualized Treatment for Patients With Familial Hypercholesterolemia
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Tada Hayato
Takamura Masayuki
Kawashiri Masa-aki
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Abstract
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Familial hypercholesterolemia (FH) is one of the most common and, therefore, important inherited disorders in preventive cardiology. This disease is mainly caused by a single pathogenic mutation in the low-density lipoprotein receptor or its associated genes. Moreover, it is correlated with a high risk of cardiovascular disease. However, the phenotype severity even in this monogenic disease significantly varies. Thus, the current study aimed to describe FH and its importance and the factors (inherited and acquired) contributing to differences in phenotype severity. Different lipid-modification therapies according to these factors can lead to individualized treatments, which are also essential in the general populations.
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KEYWORD
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Hyperlipoproteinemia type II, LDL receptors, Cardiovascular diseases
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