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KMID : 1038020150230010008
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Translational and Clinical Pharmacology
2015 Volume.23 No. 1 p.8 ~ p.14
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Statistical basis for pharmacometrics: maximum likelihood estimator and its asymptotics
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Choi Kyung-Mee
Yim Dong-Seok
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Abstract
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The maximum likelihood estimator is the point estimator of the top priority in statistical data analysis because of its optimum properties for large sample size. While the maximum likelihood estimator is widely used, it has been an abstruse subject for pharmacometricians without statitics bagkround because of high dimensional calculus and asymptotic theories. This tutorial provides a general and brief introduction to the maximum likelihood estimator and its related caluculus for non-statisticians.
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KEYWORD
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Taylor series, Newton-Raphson method, Maximum Likelihood Estimator
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