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KMID : 1038020170250030134
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Translational and Clinical Pharmacology
2017 Volume.25 No. 3 p.134 ~ p.137
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case of Waldenstrom’s macroglobulinemia treated using clarithromycin and prednisolone
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Ohe Masashi
Hashino Satoshi
Shida Haruki
Horita Tetsuya
Sugiura Mitsuru
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Abstract
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We report a case of Waldenstrom’s macroglobulinemia (WM) treated using clarithromycin (CAM) and prednisolone (PSL). An 84-year-old woman was admitted to our hospital for bleeding after a tooth extraction and hematuria. Computed tomography showed multiple ill-defined nodules in the omentum (omental cake). Although the cause of the omental cake remained unclear, the patient was diagnosed with WM, based on the detection of M-protein of immunoglobulin (Ig) M in serum and lymphoplasmacytes in bone marrow. The bleeding tendency in the patient may have been due to acquired hemophilia and/or hyper IgM-induced platelet dysfunction. The patient was treated using CAM (800 mg/day) and PSL (10 mg/day). As a result, IgM levels gradually decreased. Because the omental cake contracted along with improvement in IgM, it was thought to be lymphoplasmacytic lymphoma-like lymphoma. This case shows that treatment using CAM and PSL may be effective in some cases of WM.
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KEYWORD
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Macroglobulinemia, Lymphoma, Clarithromycin, Prednisolone
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