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KMID : 1038020200280010017
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Translational and Clinical Pharmacology
2020 Volume.28 No. 1 p.17 ~ p.33
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Possibility of pharmacokinetic drug interaction between a DPP-4 inhibitor and a SGLT2 inhibitor
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Gu Nam-Yi
Park Sang-In
Chung Hye-Won
Jin Xuanyou
Lee Seung-Hwan
Kim Tae-Eun
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Abstract
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Type 2 diabetes mellitus is a multifactorial condition characterized by high level of sugar in the blood. To control hyperglycemia, combination therapy is recommended if monotherapy fails to achieve glycemic control. The combination of a dipeptidyl peptidase-4 (DPP-4) inhibitor and a sodium-glucose cotransporter type 2 (SGLT2) inhibitor is a promising option of the combination therapies in terms of safety as well as efficacy. Despite of the value of combination therapy of these two agents, the pharmacokinetic drug interactions between these two classes of agents have been evaluated in a few drugs. Thus, we reviewed the potential pharmacokinetic drug interaction based on the in vitro metabolism- and transporter-mediated drug interaction information as well as drug interaction studies in human, between a DPP-4 inhibitor and a SGLT2 inhibitor which are marketed in South Korea.
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KEYWORD
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Dipeptidyl-peptidase IV inhibitors, Sodium-glucose transporter 2 inhibitors, Drug interaction, Pharmacokinetics
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