|
KMID : 1039020130360010058
|
|
The Ewha Medical Journal
2013 Volume.36 No. 1 p.58 ~ p.61
|
|
|
Angiogenic Inhibitor Induced Complicated Reflux Esophagitis
|
|
Ryu Jae-In
Jung Hye-Kyung
Cho Min-Sun
Lee Min-Jin
Song Myung-Eun
Oh Da-Yeon
Song Ha-Eung
|
|
|
Abstract
|
|
|
|
Sunitinib an inhibitor of the vascular endothelial growth factor receptor, is highly effective against renal cell carcinoma and is now widely used in patients with metastatic disease. Gastroesophageal reflux disease (GERD) is rarely reported as a side effect of sunitinib. We report two cases of GERD with upper gastrointestinal bleeding related to sunitinib administration. Both cases responded well to conservative management. Microscopic findings in both cases showed cellular atypia such as hyperchromasia, increases in nuclear size, and multinucleation. The cellular atypia of the squamous mucosa appears to be associated with reparative processes.
|
|
|
KEYWORD
|
|
|
Angiogenesis inhibitor, Gastroesophageal reflux, Metastatic renal cell carcinoma, Sunitinib
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|