KMID : 1098420100180040231
|
|
Korean Journal of Medicinal Crop Science 2010 Volume.18 No. 4 p.231 ~ p.237
|
|
Effects of Water Extract of Glycyrrhiza uralensis on ¥â-Hexosaminidase Release and Expression of the Cytokines of RBL-2H3 Mast Cells
|
|
Kim Jeong-Mi
Kim Dae-Jung Kim Tae-Hyuk Baek Jong-Mi Kim Hyun-Sook Choe Myeon
|
|
Abstract
|
|
|
The present study was conducted to investigate the anti-allergic reaction with Glycyrrhiza uralensis. We examined cell viability, ¥â-hexosaminidase release, IL-4 and IL-13 mRNA expression from RBL-2H3 cell after pre-treatment with 0, 100, 250, 500, 1000§¶/§¢ of Glycyrrhiza uralensis water extracts. Effects of Glycyrrhiza uralensis on the degranulation and pro-inflammatory cytokines (IL-4 and IL-13) expression were evaluated with ¥â-hexosaminidase assay, and RT-PCR analysis. We observed that Glycyrrhiza uralensis concentrations from 100§¶/§¢ to 1000§¶/§¢ had no effect on cell survival. The release of ¥â-hexosaminidase decreased significantly with all concentrations of Glycyrrhiza uralensis extracts. The expression of the IL-4 and IL-13 mRNA were decreased by Glycyrrhiza uralensis in dose-dependent manner. These results that Glycyrrhiza uralensis has an anti-histamin effects and controls IL-4, IL-13 secretion on allergic reaction.
|
|
KEYWORD
|
|
Glycyrrhiza uralensis, Anti-Allergic, RBL-2H3, IL-4, IL-13, ¥â-hexosaminidase
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|