KMID : 1098420160240010038
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Korean Journal of Medicinal Crop Science 2016 Volume.24 No. 1 p.38 ~ p.46
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Whitening and Anti-Wrinkle Effects of Tremella Fuciformis Extracts
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Lee Kwang-Ho
Park Hyun-Soo Yoon Il-Joo Shin Young-Bong Baik Young-Chan Kooh Dae-Ho Kim Sung-Kew Jung Ho-Kyung Sim Mi-Ok Cho Hyun-Woo Jung Won-Seok Kim Myoung-Seok
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Abstract
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Background : The white jelly mushroom (Tremella fuciformis), one of the most popular edible fungi, has medicinal properties. However, the effects of T. fuciformis in skin whitening or anti-wrinkle efficacy has not been defined to date. The aim of the present study was to investigate the effects of T. fuciformis extracts on whitening and anti-wrinkle efficacy in skin cells.
Methods and Results : We prepared T. fuciformis extracts with water. The extracts (80¡É) contained 12.11 §·/g polyphenol and 8.54 §·/g flavonoid concentration. T. fuciformis extracts markedly decreased melanin contents and tyrosinase activity in ¥á-MSHstimulated melanocytes (B16F10 cells). In addition, the mRNA expression of melanin formation factors, such as microphthalmiaassociated transcription factor (MITF), tyrosinase-related protein-1 (TRP-1) and tyrosinase-related protein-2 (TRP-2) were significantly down-regulated in ¥á-MSH-stimulated melanocyte. Furthermore, T. fuciformis extracts increased the synthesis of type I procollagen and reduced mRNA expression of matrix metalloproteinase 1 (MMP-1) in the human dermal fibroblast (HDFn cells). These data indicated that T. fuciformis extracts induce repression of cellular melanogenesis and protect against wrinkles caused by UVB-stimulated damage.
Conclusions : Thus T. fuciformis extracts could be a cosmetic candidate for skin whitening and anti-wrinkle effects.
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KEYWORD
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Tremella fuciformis, Anti-Wrinkle, Collagen, Melanin, Natural Product, Whitening
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