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KMID : 1099620140110030198
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Korean Journal of Spine
2014 Volume.11 No. 3 p.198 ~ p.201
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Rosai-Dorfman Disease in Thoracic Spine: A Rare Case of Compression Fracture
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Kim Do-Young
Park Ji-Hye
Shin Dong-Ah
Yi SEung
Ha Yoon
Yoon Do-Heum
Kim Keung-Nyun
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Abstract
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Sinus histiocytosis with massive lymphadenopathy known as Rosai-Dorfman disease is characterized by painless bilateral cervical lymphadenopathy. Extranodal manifestations are uncommon and spinal involvement is rare. A 15-year-old man presented with intermittent midthoracic back pain only. He had no specific findings on neurologic examinations, hematologic and biochemical laboratory tests. Radiological examination of thoracic spine revealed collapse of T6 vertebrae with thoracic kyphosis and osteolytic lesion of T12 vertebra body. He underwent a removal of bone tumor, anterior reconstruction with mesh and pedicle screw fixation via posterior approach for pathologic confirmation and stabilization. Histopathologic study of the lesion revealed focal infiltration of large histiocytes showing emperipolesis. Immunochemistry stain of histiocytes was positive for CD68 and S-100 but negative for CD1a. This report presents a rare case and literature review of extranodal Rosai-dorfman disease in thoracic spine.
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KEYWORD
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Rosai-Dorfman disease, Extranodal involvement, Thoracic vertebra, Compression fracture
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