KMID : 1100120240310020162
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´ëÇÑ°ñ´ë»çÇÐȸÁö 2024 Volume.31 No. 2 p.162 ~ p.168
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Two-Year Outcomes of Daily and Twice-Weekly Teriparatide Treatment in Postmenopausal Women with Severe Osteoporosis: A Randomized Non-Blinded Prospective Study
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Takeshi Mochizuki
Koichiro Yano Katsunori Ikari Ken Okazaki
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Abstract
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Background: The long-term effects of daily teriparatide (D-TPTD) and twice-weekly TPTD (W-TPTD) injections are compared among postmenopausal women with severe osteoporosis.
Methods: A total of 102 patients were enrolled and randomly allocated into two groups for the administration of either D-TPTD or W-TPTD. Treatment efficacy was measured as the percentage change in bone mineral density (¥ÄBMD) from baseline in the lumbar spine, total hip, and femoral neck. The findings were compared between the two groups.
Results: At 24 months after treatment, the persistence rates and medication possession ratios in the D-TPTD and W-TPTD groups were 68.6% and 56.9%, and 87.8% and 92.0%, respectively. The ¥ÄBMD in the lumbar spine, total hip, and femoral neck were 15.6%¡¾10.2%, 5.3%¡¾ 6.3%, and 5.5%¡¾6.2%, respectively, in the D-TPTD group; and 9.5%¡¾7.9%, 2.3%¡¾6.2%, and 3.1%¡¾7.4%, respectively, in the W-TPTD group following 24 months of treatment. The ¥ÄBMD of the lumbar spine (P=0.008) at 24 months and total hip (P=0.024) at 18 months differed significantly between the two groups.
Conclusions: D-TPTD administration resulted in a significantly higher BMD in the lumbar spine and total hip, supporting this therapeutic regimen for postmenopausal women with severe osteoporosis.
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KEYWORD
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Bone mineral density, Daily, Osteoporosis, Teriparatide, Twice weekly
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