KMID : 1100220150140040168
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Dementia and Neurocognitive Disorders 2015 Volume.14 No. 4 p.168 ~ p.171
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Atypical Early-Onset Alzheimer¡¯s Disease Dementia Diagnosed by Biomarker Study
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Lee Seung-Keun
Shin Dae-Seop Shin Ho-Sik Park Sun-Ah
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Abstract
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Background : The described clinical characteristics of early-onset Alzheimer¡¯s disease (EOAD) are distinct from that of late-onset AD. We reported a patient with atypical EOAD.
Case Report: A 54-year-old, truck driver developed gradual visuospatial, language and calculation deficits for 3 months. The neuropsychological impairments were extensive. Brain MRI revealed asymmetric atrophy in left medial temporal lobe along with distinct widening of sylvian fissure. (18)F-florbetapir-positron emission tomography (PET) showed a high uptake in the cortex. Further, the profiles of cerebrospinal fluid (CSF) biomarker were compatible with AD.
Conclusions: We diagnosed the patient as EOAD based on the result of biomarker study. Increased A©¬ burden was identified through amyloid PET imaging and decreased CSF A¥â level. The high rise of CSF Tau proteins was in agreement with the patient¡¯s extensive and rapid cognitive decline. This case report demonstrates the importance of AD biomarker study in confronting early-onset dementia with atypical clinical presentation.
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KEYWORD
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amyloid imaging, biomarker, cerebrospinal fluid, early-onset Alzheimer¡¯s disease, positron emission tomography
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