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KMID : 1100320160330010040
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Yeungnam University Journal of Medicine
2016 Volume.33 No. 1 p.40 ~ p.43
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Rapidly resolved IgG4-related retroperitoneal fibrosis after steroid pulse therapy
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Jeung Soo-Min
Kim Hyo-Sang
Seo Yu-Ri
Yoon Hee-Young
Lee Nah-Kyum
Park Shin-Hee
Seo Bo-Mi
Park Su-Yeon
Park Su-Kil
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Abstract
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Retroperitoneal fibrosis (RF) is a disorder characterized by the presence of a retroperitoneal mass and concurrent systemic inflammation. Some cases of RF are recognized as belonging to the spectrum of immunoglobulin G4-related disease (IgG4-RD). Glucocorticoids are highly effective for treatment of retroperitoneal fibrosis, although the optimal dose and duration of therapy have not been established. An initial dose of prednisone (40-60 mg) daily is usually administered with a tapering scheme. We report on a 55-year-old man diagnosed with IgG4-related RF and successfully treated with a 3-day course of daily 250 mg (4 mg/kg) intravenous methylprednisolone, which resulted in the prompt resolution of urinary obstruction and systemic symptoms.
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KEYWORD
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Glucocorticoids, IgG4-related disease, Retroperitoneal fibrosis, Steroid pulse therapy
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