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KMID : 1100320160330020125
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Yeungnam University Journal of Medicine
2016 Volume.33 No. 2 p.125 ~ p.129
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A patient with stress induced cardiomyopathy that occurred after cessation of hormone replacement therapy for panhypopituitarism
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Nam Seoung-Wan
Lee Jun-Won
Sim Jeong-Han
Pack Hyun-Sung
Im Chang-Jo
Lim Jung-Soo
Ahn Sung-Gyun
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Abstract
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Stress induced cardiomyopathy (SC) is characterized by transient left ventricular (LV) dysfunction in the absence of coronary artery disease. We report on a patient with panhypopituitarism who developed SC resulting from withdrawal of hormonal replacement therapy (HRT). A 52-year-old male visited our hospital for progressively worsening dyspnea. The patient had discontinued HRT 7 days ago, which had been administered for 18 months after transsphenoidal adenomectomy for pituitary macroadenoma. Initial electrocardiogram showed marked sinus bradycardia. Transthoracic echocardiography showed apical ballooning with an LV ejection fraction of 25%. No significant obstructive lesions were observed on coronary angiography. With a clinical diagnosis of SC associated with panhypopituitarism, HRT was restarted, including glucocorticoid and thyroxine, along with standard heart failure management. His LV function had normalized at 2-month follow-up. He remains asymptomatic and administration of beta-blocker and angiotensin converting enzyme inhibitor were discontinued He currently only requires HRT.
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KEYWORD
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Takotsubo cardiomyopathy, Stress cardiomyopathy, Hypopituitarism
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