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KMID : 1100320190360020155
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Yeungnam University Journal of Medicine
2019 Volume.36 No. 2 p.155 ~ p.158
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Imatinib-induced hepatitis treated by corticosteroids in a patient with metastatic gastrointestinal stromal tumor
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Kang Min-Kyu
Lee Heon-Ju
Choi Joon-Hyuk
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Abstract
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Imatinib mesylate is currently used as the first-line treatment for metastatic gastrointestinal stromal tumors (GISTs). Imatinib-induced hepatotoxicity in patients with GIST is very rare. Its features vary from subclinical elevation of serum aminotransferase to clinically apparent acute hepatitis, which is associated with immunologic reactions. Imatinib-induced hepatotoxicity with autoimmune-like features can be treated by the discontinuation of imatinib mesylate and the administration of oral steroids. Here, we report a case of late-onset imatinib-induced hepatitis with autoimmune-like features in a patient with metastatic GIST, which was improved by oral corticosteroids.
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KEYWORD
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Corticosteroids, Drug-induced liver injury, Gastrointestinal stromal tumors, Imatinib mesylate
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